https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31927 P > 0.05). When the data were analysed according to disability, participants with moderate/severe disability showed significantly improved gross motor function following cathodal stimulation compared with sham (P=0.014). However, this was accompanied by decreased key grip strength in the unaffected hand (P=0.003). We are unable to endorse the use of anodal and cathodal tDCS in the management of upper limb dysfunction in chronic stroke patients. Although there appears to be more potential for the use of cathodal stimulation in patients with severe disability, the effects were small and must be considered with caution as they were accompanied by unanticipated effects in the unaffected upper limb.]]> Wed 24 Nov 2021 15:53:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33111 Wed 11 Oct 2023 14:07:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27856 Wed 11 Apr 2018 10:16:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27854 Wed 09 Feb 2022 15:57:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42438 Tue 23 Aug 2022 10:26:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38215 50 years, n = 92). The latter were further subdivided into two subgroups with (CV+, n = 25) and without (CV−, n = 67) cardiovascular risk factors. Arterial pulsatility was measured using cardiac-gated phase-contrast flow quantification sequence and three indexes of whole-brain white matter microstructural organization [i.e., fractional anisotropy (FA), radial diffusivity (RaD), mean diffusivity (MD)] were derived from diffusion-weighted imaging (DWI). Cognitive ability was assessed using global cognitive functioning (MoCA) and a measure of working memory [sensitivity (d′) from a 2-back task]. Neither the whole group analysis nor the younger adult group showed an association between measures of arterial pulsatility, global white matter microstructural organization, and cognition. In older adults, higher MD and RaD were associated with increased arterial pulsatility and poorer working memory performance. The indirect pathway from arterial pulsatility to working memory performance via both MD and RaD measures was significant in this group. Interestingly, a comparison of CV+ and CV− subgroups showed that this mediating relationship was only evident in older adults with at least one CV risk factor. These findings are consistent with cardiovascular risk factors as underlying arterial, white matter, and cognitive decline in cognitively normal older adults.]]> Fri 13 Aug 2021 14:31:48 AEST ]]>